| Match | Journée 1 08/01/2022 |
| Yeovil Town - Bournemouth | 1 - 3 |
| Boreham wood - AFC Wimbledon | 2 - 0 |
| Stoke City - Leyton Orient | 2 - 0 |
| Swansea City - Southampton | 2 - 3 |
| Chelsea - Chesterfield | 5 - 1 |
| Liverpool - Shrewsbury | 4 - 1 |
| Cardiff City - Preston | 2 - 1 |
| Coventry City - Derby County | 1 - 0 |
| Burnley - Huddersfield | 1 - 2 |
| West Bromwich Albion - Brighton and Hove Albion | 1 - 2 |
| Kidderminster Harriers - Reading | 2 - 1 |
| Leicester City - Watford | 4 - 1 |
| Mansfield Town - Middlesbrough | 2 - 3 |
| Hartlepool United - Blackpool | 2 - 1 |
| Hull City - Everton | 2 - 3 |
| Bristol City - Fulham | 0 - 1 |
| Tottenham - Morecambe | 3 - 1 |
| Millwall - Crystal Palace | 1 - 2 |
| Port Vale - Brentford | 1 - 4 |
| Swindon Town - Manchester City | 1 - 4 |
| Wigan - Blackburn rovers | 3 - 2 |
| Luton Town - Harrogate Town | 4 - 0 |
| Birmingham City - Plymouth Argyle | 0 - 1 |
| Manchester united - Aston villa | 1 - 0 |
| Wolverhampton Wanderers - Sheffield United | 3 - 0 |
| Newcastle united - Cambridge United | 0 - 1 |
| Peterborough - Bristol Rovers | 2 - 1 |
| West Ham - Leeds United | 2 - 0 |
| Queens PR - Rotherham United | 1 - 1 (tab 8-7) |
| Charlton Athletic - Norwich City | 0 - 1 |
| Nottingham Forest - Arsenal | 1 - 0 |
| Barnsley - Barrow AFC | 5 - 4 |