| Match | Journée 1 24/08/2021 |
| Oldham Athletic - Accrington Stanley | 0 - 0 (tab 5-4) |
| Norwich City - Bournemouth | 6 - 0 |
| Swansea City - Plymouth Argyle | 4 - 1 |
| Wigan - Bolton | 0 - 0 (tab 5-4) |
| Huddersfield - Everton | 1 - 2 |
| Sheffield United - Derby County | 2 - 1 |
| Stoke City - Doncaster Rovers | 2 - 0 |
| Shrewsbury - Rochdale | 0 - 2 |
| Morecambe - Preston | 2 - 4 |
| Blackpool - Sunderland | 2 - 3 |
| Leeds United - Crewe Alexandra | 3 - 0 |
| Barrow AFC - Aston villa | 0 - 6 |
| Brentford - Forest Green Rovers | 3 - 1 |
| Millwall - Cambridge United | 3 - 1 |
| Cardiff City - Brighton and Hove Albion | 0 - 2 |
| Birmingham City - Fulham | 0 - 2 |
| Gillingham - Cheltenham Town | 1 - 1 (tab 4-5) |
| Queens PR - Oxford United | 2 - 0 |
| Stevenage Borough - Wycombe | 2 - 2 (tab 3-5) |
| Northampton Town - AFC Wimbledon | 0 - 1 |
| Watford - Crystal Palace | 1 - 0 |
| Nottingham Forest - Wolverhampton Wanderers | 0 - 4 |
| Newcastle united - Burnley | 0 - 0 (tab 3-4) |
| Newport County - Southampton | 0 - 8 |
| West Bromwich Albion - Arsenal | 0 - 6 |