| AZ Alkmaar | 2 - 0 | Shelbourne | 27/11/2025 18:45 |
| Slovan Bratislava | 2 - 1 | Rayo Vallecano | 27/11/2025 18:45 |
| Rakow Czestochowa | 4 - 1 | Rapid Vienne | 27/11/2025 18:45 |
| Omonia Nicosie | 2 - 0 | Dynamo Kiev | 27/11/2025 18:45 |
| Lech Poznan | 2 - 0 | Lausanne Sport | 27/11/2025 18:45 |
| Universitatea Craiova | 1 - 0 | FSV Mainz | 27/11/2025 18:45 |
| Sigma Olomouc | 2 - 1 | NK Celje | 27/11/2025 18:45 |
| Zrinjski Mostar | 2 - 1 | BK Hacken Goteborg | 27/11/2025 18:45 |
| Hamrun Spartans | 3 - 1 | Lincoln Red Imps | 27/11/2025 18:45 |
| Fiorentina | 0 - 1 | AEK Athenes | 27/11/2025 21:00 |
| Shamrock | 1 - 2 | Shakhtar Donetsk | 27/11/2025 21:00 |
| Legia Varsovie | 0 - 1 | Sparta Prague | 27/11/2025 21:00 |
| Strasbourg | 2 - 1 | Crystal Palace | 27/11/2025 21:00 |
| Jagiellonia Bialystok | 1 - 0 | KuPS Kuopio | 27/11/2025 21:00 |
| Rijeka | 0 - 0 | AEK Larnaca | 27/11/2025 21:00 |
| Aberdeen | 1 - 1 | FC Noah | 27/11/2025 21:00 |
| Drita | 1 - 0 | Shkendija 79 | 27/11/2025 21:00 |
| Breidablik | 2 - 2 | Samsunspor | 27/11/2025 21:00 |
Les jeux d'argent et de hasard sont interdits aux mineurs (-18 ans)