| AS Roma | 2 - 1 | Midtjylland | 27/11/2025 18:45 |
| FC Porto | 3 - 0 | Nice | 27/11/2025 18:45 |
| Feyenoord | 1 - 3 | Celtic Glasgow | 27/11/2025 18:45 |
| Lille | 4 - 0 | Dinamo Zagreb | 27/11/2025 18:45 |
| Aston villa | 2 - 1 | Young Boys Berne | 27/11/2025 18:45 |
| Fenerbahce | 1 - 1 | Ferencvaros | 27/11/2025 18:45 |
| Paok Salonique | 1 - 1 | Brann Bergen | 27/11/2025 18:45 |
| Viktoria Plzen | 0 - 0 | Fribourg | 27/11/2025 18:45 |
| Ludogorets Razgrad | 3 - 2 | Celta vigo | 27/11/2025 18:45 |
| Glasgow Rangers | 1 - 1 | Sporting Braga | 27/11/2025 21:00 |
| Betis seville | 2 - 1 | FC Utrecht | 27/11/2025 21:00 |
| Bologne | 4 - 1 | Wustenrot Salzburg | 27/11/2025 21:00 |
| Etoile Rouge Belgrade | 1 - 0 | Steaua Bucarest | 27/11/2025 21:00 |
| Maccabi Tel Aviv | 0 - 6 | Lyon | 27/11/2025 21:00 |
| Racing Genk | 2 - 1 | FC Bale | 27/11/2025 21:00 |
| Nottingham Forest | 3 - 0 | Malmo FF | 27/11/2025 21:00 |
| Panathinaikos | 2 - 1 | Sturm Graz | 27/11/2025 21:00 |
| Go Ahead Eagles | 0 - 4 | Vfb Stuttgart | 27/11/2025 21:00 |
Les jeux d'argent et de hasard sont interdits aux mineurs (-18 ans)